By Antonius M. VanDongen
The NMDA receptor performs a severe position within the improvement of the significant apprehensive procedure and in grownup neuroplasticity, studying, and reminiscence. accordingly, it isn't astounding that this receptor has been broadly studied. in spite of the fact that, regardless of the significance of rhythms for the sustenance of existence, this element of NMDAR functionality is still poorly studied. Written via one of many world’s major professionals on NMDA receptors, Biology of the NMDA Receptor brings jointly nearly the entire gamers during this very important box.
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Additional info for Biology of the NMDA Receptor
P. , Genetic enhancement of learning and memory in mice, Nature, 401, 63, 1999. 47. Kohr, G. , Intracellular domains of NMDAR subtypes are determinants for longterm potentiation induction, J. , 23, 10791, 2003. 48. , Roles of NMDAR NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex, Eur. J. , 22, 485, 2005. 49. Weitlauf, C. , Activation of NR2A-containing NMDARs is not obligatory for NMDAR-dependent long-term potentiation, J. , 25, 8386, 2005. 50. Berberich, S. , Lack of NMDAR subtype selectivity for hippocampal long-term potentiation, J.
1). 2) allows the detailed study of changes in synaptic function and neurotransmission that may be relevant to HD pathogenesis or progression, or underlie neuronal dysfunction prior to death. Studies of corticostriatal pathway function in this context revealed both pre- and post-synaptic changes associated with mhtt expression. Alterations of synaptic plasticity have been documented in several brain regions. The next section briefly reviews these changes focusing on those that directly impact or rely on NMDAR function.
19, 4472, 1999. 89. Y. , Neural activity and the dynamics of central nervous system development, Nat. , 7, 327, 2004. 90. K. , How do dendrites take their shape? Nat. , 4, 2001. 91. , Dendritic arbor development and synaptogenesis, Curr. Opin. , 11, 118, 2001. 92. Rajan, I. , Glutamate receptor activity is required for normal development of tectal cell dendrites in vivo, J. , 18, 7836, 1998. 93. C. , Dendrite growth increased by visual activity requires NMDAR and Rho GTPases, Nature, 419, 475, 2002.