By Brian M. Frier, Miles Fisher
With heart problems turning into the commonest explanation for dying in individuals with diabetes, curiosity within the review and therapy of center disorder in those patients has been reawakened. This publication examines constructing issues from a principally cardiological perspective, covering both pharmacological and non-pharmacological interventions.
The DIGAMI examine at the use of intravenous insulin infusion on the time of myocardial infarction (MI) has prompted various dialogue papers at the most sensible therapy of MI within the diabetic patient. The UKPDS has proven that remedy of kind 2 diabetes doesn't decrease cardiovascular end-points considerably, yet that competitive therapy of blood strain can do so. In addition, sub-group research from a number of huge cardiovascular trials has proven that therapy with statins, anti-platelet treatment, ACE inhibitors and different medicinal drugs also will decrease cardiovascular occasions in individuals with diabetes.
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Additional info for Diabetic cardiology
Dandona P, Aljada A, Dhindsa S, Garg R (2003). Insulin as an anti-inflammatory and antiatherosclerotic hormone. Clinical Cornerstone Supplement 4: S13–20. REFERENCES 33 Das UN (2004). Metabolic syndrome X: an inflammatory condition? Current Hypertension Reports 6: 66–73. Eberly LE, Stamler J, Neaton JD (2003). Relation of triglyceride levels, fasting and nonfasting, to fatal and nonfatal coronary heart disease. Archives of Internal Medicine 163: 1077–83. Evans JM, Ogston SA, Emslie-Smith A, Morris AD (2006).
High sensitivity C-reactive protein in cardiovasular disease and diabetes: evidence for a clinical role? British Journal of Diabetes and Vascular Disease 6: 5–8. Sattar N (2006b). The metabolic syndrome: should current criteria influence clinical practice? Current Opinion in Lipidology 17: 404–11. REFERENCES 35 Sattar N, Lowe GD (2006). High sensitivity C-reactive protein and cardiovascular disease: an association built on unstable foundations? Annals of Clinical Biochemistry 43: 252–6. Sattar N, McInnes IB (2005).
Microalbuminuria is defined as low levels of urinary albumin excretion of 30–300 mg/day. 6 INFLAMMATION 25 Microalbuminuria is highly prevalent; in hypertensive and diabetic populations, its prevalence varies from 10 to 40%. It is interesting that microalbuminuria also is found frequently in seemingly healthy individuals (5–7%). Dysfunction of the vascular endothelium is regarded as an important factor in the pathogenesis of diabetic micro- and macroangiopathy (Basi and Lewis, 2006). The close linkage between microalbuminuria and endothelial dysfunction in diabetes has been used to explain the fact that microalbuminuria is a risk marker for atherothrombosis, and this topic has been widely reviewed by others (Schalkwijk and Stehouwer, 2005).