By Christian Behl
It is celebrated that estrogen is "somehow” a protecting hormone for numerous age-related issues. This ebook offers an outstanding wisdom of estrogen’s neuroprotective actions within the mind with a different emphasis on neurodegenerative issues corresponding to Alzheimer’s ailment. the focal point is (1) to explain the biochemical, molecular, and mobile foundation of the protecting job of estrogen and (2) to move this data into the hospitals through discussing preventive and healing methods akin to estrogen alternative treatment for post-menopausal girls. along with updated info on estrogen and the mind, this ebook explains in a hugely comprehensible demeanour molecular and mobile concepts wherein easy facts were gathered. The reader, that can contain the pro expert in addition to the non-specialist, also will achieve perception into the medical move means of wisdom from simple technological know-how to the scientific scenario and for this reason "from bench to bed”.
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Extra resources for Estrogen — Mystery Drug for the Brain?: The Neuroprotective Activities of the Female Sex Hormone
1997; 1998; Gustafsson, 1999; Shughrue and Merchenthaler, 2000). The broad expression pattern of ERp indeed points towards a more general role of this type of estrogen receptor in several tissues and it will be an important task to elucidate the differential physiological roles of ERp compared with those of ERa. This knowledge is of central importance with respect to the use of estrogens as drug in estrogen replacement therapy (ERTj see page 136) or for the application of specific ER antagonists to treat estrogen-dependent breast cancers.
1987 cloned the mouse ERa). Since estrogen has activities in various target tissues, during the development and in the adult organisms it has been speculated from very early on that there might be additional types of ERs and ER homologs. , 1995). , 1988), which do not actually bind estrogens. Receptors without known ligands are called orphan receptors. , 1999: Giguere, 1999). All the experimental data collected concerning estrogen's physiological and pathophysiological functions were discussed in the light of the existence of only one specific ER.
It binds to its receptor in the membrane which is occurring - more or less - in one step. The protein hormone needs to be recognized by its receptor, which then turns on a cascade of intracellular downstream signaling events. In contrast, the steroid binds to the receptor and follows the receptor in to the nucleus. The steroid receptor on the other hand needs to be a specially designed molecule since it has to fulfill quite different functions. The ability to perform these different functions is provided by the structure of the steroid receptor.