By Christophe Le Tourneau, Maud Kamal
This unique booklet offers readers with an outline of the most recent advancements in customized drugs scientific trials in oncology. the subjects lined diversity from the reason at the back of this new iteration of medical trials and the newest statistical types for high-throughput molecular options, bioinformatics, high-throughput screening molecular options and the demanding situations entailed via enforcing them in day-by-day perform. It additionally covers the most important function of pathology within the validation of molecular effects and the advanced evaluation of predictive biomarkers. the various themes lined are supplemented by way of specific concrete examples in line with the SHIVA trial.
The authors are all individuals of the French Curie Institute, one of many world’s prime melanoma study institutions.
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Additional info for Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine
The presence of isodisomy in a tumor genome can highlight a simple mechanism to obtain biallelic inactivation of a tumor suppressor gene which is already mutated or disrupted on one allele (Fig. 4). 5 Structural Aberration As translocations directly affect a small number of genes, the role of many translocations in cancer causation has become much clearer over the years. These translocations can be within a chromosome (with the homologous chromosome or inversion inside the same chromosome). They can also occur between different chromosomes and in a nonreciprocal manner (often with loss of material) or can form ring chromosome.
Thanks to Dr. Gudrun Schleiermacher, MD PhD, and Chicard Mathieu for their collaboration on ctDNA. References André F, Bachelot T, Commo F et al (2014) Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01/UNICANCER). Lancet Oncol 15(3):267–274. 1016/S1470-2045(13)706119. Epub 2014 Feb 7 Bickmore WA (2001) Karyotype analysis and chromosome banding. Nature. 1038/npg. 0001160 Davies JJ, Wilson IM, Lam WL (2005) Array CGH technologies and their applications to cancer genomes.
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