By Duarte Miguel F. Prazeres
The booklet addresses the fundamentals, functions, and production of plasmid biopharmaceuticals. The survey of the main correct features of plasmids presents the fundamentals for designing plasmid items (applications) and tactics (manufacturing). Key beneficial properties that the authors contain within the e-book are: i) consistency and transparent line of path, ii) an in depth use of cross-referencing among the person chapters, iii) a rational integration of chapters, iv) appellative figures, tables and schemes, and v) an up-to-date, yet chosen selection of references, with a spotlight on key papers.Content:
Chapter 1 old viewpoint (pages 1–34):
Chapter 2 Gene move with Plasmid Biopharmaceuticals (pages 35–68):
Chapter three Product and technique improvement (pages 69–84):
Chapter four constitution (pages 85–128):
Chapter five Analytical Characterization (pages 129–165):
Chapter 6 supply (pages 167–210):
Chapter 7 moral and questions of safety (pages 211–242):
Chapter eight Human and Veterinary Markets (pages 243–271):
Chapter nine Human Case experiences: Pandemic Influenza and significant Limb Ischemia (pages 273–300):
Chapter 10 Veterinary Case reviews: West Nile, Infectious Hematopoietic Necrosis, and cancer (pages 301–325):
Chapter eleven strong production perform and Validation (pages 327–355):
Chapter 12 Product requisites and qc (pages 357–390):
Chapter thirteen cellphone tradition (pages 391–414):
Chapter 14 an summary of Downstream Processing (pages 415–425):
Chapter 15 basic Isolation (pages 427–453):
Chapter sixteen Intermediate restoration (pages 455–495):
Chapter 17 ultimate Purification (pages 497–542):
Chapter 18 strategy Synthesis (pages 543–562):
Chapter 19 Concluding comments and Outlook (pages 563–578):
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Additional info for Plasmid Biopharmaceuticals: Basics, Applications, and Manufacturing
46. Lehrman S. Virus treatment questioned after gene therapy death. Nature. 1999;401:517–518. 47. Somia N, Verma IM. Gene therapy: Trials and tribulations. Nature Reviews. Genetics. 2000;1:91–99. 48. Zallen DT. US gene therapy in crisis. Trends in Genetics. 2000;16:272–275. 49. Raper SE, Chirmule N, Lee FS, et al. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Molecular Genetics and Metabolism. 2003;80:148–158.
140 Manufactured and sold by VGX Animal Health, Inc. 140 According to the company’s description, the plasmid is delivered to muscle cells by intramuscular injection followed by electroporation with the portable electrokinetic device, cellectra™. The GHRH, which is produced by the transfected cells, then induces the production and secretion of the endogenous growth hormone. 141 LifeTide SW 5 thus became the first plasmid biopharmaceutical approved for the gene therapy of animals produced with the intent of supplying the human food chain.
2003;19:505–513. 3. Seegmiller JE. Genetic and molecular basis of human hereditary diseases. Clinical Chemistry. 1967;13:554–564. 4. Avery OT, MacLeod CM, McCarty M. Studies on the chemical nature of the substance inducing transformation of pneumococcal types. The Journal of Experimental Medicine. 1944;79:137–158. 5. Keeler CE. Gene therapy. The Journal of Heredity. 1947;38:294–298. 6. Mullin D. Prometheus in Gloucestershire: Edward Jenner, 1749-1823. The Journal of Allergy and Clinical Immunology.