By A. Rich (auth.), Professor Dr. Volker Erdmann, Prof. Dr. hab. Jan Barciszewski, Professor Dr. Jürgen Brosius (eds.)
Developments during the last few years have published the extraordinary versatility of RNA in any compartment of the mobile, projects that were considered solely within the realm of proteins or even past. The chapters during this booklet written by means of prime investigators within the box supply perception into numerous promising avenues the place RNA and nucleic acid derivatives together with antisense RNAs, comparable to siRNA, miRNAs, amplification/selection (SELEX) generated aptamers in addition to ribozymes are on the threshold of impacting medicine.
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Extra resources for RNA Towards Medicine
Example text
The open reading frame encoding hld mRNA (hemolysin δ) comprises the hairpins 3 to 5. b The 5 region of RNAIII binds to a 5 segment of hla mRNA, and sequesters the anti-Shine and Dalgarno sequence, activating hla translation (Morfeldt et al. 1995). c The 3 domain of RNAIII binds to the ribosome binding site of spa mRNA, inhibits translation, and induces rapid degradation via the double-stranded endoribonuclease III (Huntzinger et al. 2005). The initial contacts probably involved a loop– loop interaction (the sequences are shown in a and c) target specific mRNAs, require Hfq protein (Storz et al.
Genes Dev 15:2295–2306 Brescia CC, Sledjeski DD (2003) We are legion: Noncoding regulatory RNAs and Hfq. In: Barciszewski J, Erdmann VA (eds) Noncoding RNAs: molecular biology and molecular medicine. Kluwer Academic/Plenum Publishers, New York, pp 259–269 Regulatory RNAs as Mediators of Virulence Gene Expression in Bacteria 37 Brunel C, Marquet R, Romby P, Ehresmann C (2002) RNA loop–loop interactions as dynamic functional motifs. Biochimie 84:925–944 Bunce C, Wheeler L, Reed G, Musser J, Barg N (1992) Murine model of cutaneous infection with gram-positive cocci.
Moreover, the regulatory protein Hfq is required for virulence-factor expression and the action of the four Qrr RNAs (Lenz et al. 2004). Computer analysis revealed that five homologous Qrr RNAs are also present in V. parahaemolyticus, V. vulnificus, and V. harveyi (Lenz et al. 2004). Conservation of genes across species is in general a good indication of similar functions (Michel et al. 2000), suggesting that these sRNAs may also be involved in analogous quorum-sensing circuits. Indeed in V. harveyi, Qrr RNAs, and Hfq were shown to control in a coordinated way the density-dependant light production by inducing the rapid degradation of luxR mRNA at low cell density (Lenz et al.