By John P Fisher; et al
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Extra resources for Tissue engineering : principles and practices
Smaller pore sizes were found to sustain less tissue in-growth and therefore less degradation. A similar correlation was found between the overall silk concentration of the scaffold and the degradation rate—highly concentrated (~17% silk) scaffolds elicited slow degradation rates. In conclusion, based on the data available, silks classify as biodegradable materials but their degradation rates is highly dependent on the structural features and the local enzymatic pool. A debatable subject related to silk degradation is the potential for generation of amyloid-like, predominantly parallel beta-sheet containing structures, despite any evidence for such correlations and despite long history of silk sutures.
L. 2010. Mechanism of enzymatic degradation of beta-sheet crystals. Biomaterials, 31, 2926–33. , and Yamada, H. 2004. Improvement of islet culture with sericin. J Biosci Bioeng, 98, 217–9. Park, S. , Gil, E. , Kim, H. , and Kaplan, D. L. 2010. Relationships between degradability of silk scaffolds and osteogenesis. Biomaterials, 31, 6162–72. , Knight, D. , and Engstrom, W. 2005. Spider silk proteins—Mechanical property and gene sequence. Zoolog Sci, 22, 273–81. Romer, L. and Scheibel, T. 2008. The elaborate structure of spider silk: Structure and function of a natural high performance fiber.
Use of immunoblot technique for detection of human IgE and IgG antibodies to individual silk proteins. J Allergy Clin Immunol, 76, 537–42. , Lagarde, J. , and Berson, M. 2000. In vivo model of the mechanical properties of the human skin under suction. Skin Res Technol, 6, 214–21. , and Vollrath, F. 2006. Biopolymers: Shape memory in spider draglines. Nature, 440, 621. , and Vollrath, F. 2007. Time-resolved torsional relaxation of spider draglines by an optical technique. Phys Rev Lett, 98, 167402.