By Nomiyama H., Yoshie O.
ELC (EBIl-ligand chemokine) (Yoshida et al, 1997). often referred to as MIP-3;'i (macrophage inflammatory protein 3beta and Exodus-3, belongs to a unique category of CC chemokines that's hugely expressed in lymphoid tissues and has chemotactic task for lymphocytes, yet no longer for monocytes or granulocytes. ELC particularly binds and signs via CCR7/EBI1/BLR2. The human gene for ELC (SCYAI9) is found on chromosome 9pl3. that is strange in that the majority different CC chemokine genes are mapped on chromosome 17. one other CC chemokine SLC 6Ckine stocks the receptor CCR7 with ELC and has its gene at the related chromosome as ELC. even if they percentage purely 32% amino acid identity.These findings recommend that ELC and SLC have been derived from a typical ancestor and feature a task in lymphocyte homing into and trafficking inside lymphoid tissues and the thymus.
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