Epigenetic Gene Expression and Regulation by Suming Huang, Michael D Litt, C. Ann Blakey

By Suming Huang, Michael D Litt, C. Ann Blakey

Epigenetic Gene Expression and Regulation studies present wisdom at the heritable molecular mechanisms that control gene expression, give a contribution to ailment susceptibility, and element to power remedy in destiny cures.

The publication exhibits how those heritable mechanisms let person cells to set up good and targeted styles of gene expression that may be gone through telephone divisions with out DNA mutations, thereby developing how diverse heritable styles of gene law keep watch over cellphone differentiation and organogenesis, leading to a different human organism with a number of differing mobile features and tissues.

The paintings starts with simple biology, encompasses equipment, mobile and tissue association, topical concerns in epigenetic evolution and environmental epigenesis, and finally scientific affliction discovery and remedy.

Each hugely illustrated bankruptcy is geared up to in short summarize present learn, offer applicable pedagogical suggestions, pertinent equipment, appropriate version organisms, and medical examples.

  • Reviews present wisdom at the heritable molecular mechanisms that keep an eye on gene expression, give a contribution to affliction susceptibility, and aspect to power therapy in destiny therapies
  • Helps readers know how epigenetic marks are distinct, and to what volume transgenerational epigenetic alterations are instilled and probably handed onto offspring
  • Chapters are replete with medical examples to empower the fundamental biology with translational significance
  • Offers greater than a hundred illustrations to distill key techniques and decipher advanced science

Show description

By Suming Huang, Michael D Litt, C. Ann Blakey

Epigenetic Gene Expression and Regulation studies present wisdom at the heritable molecular mechanisms that control gene expression, give a contribution to ailment susceptibility, and element to power remedy in destiny cures.

The publication exhibits how those heritable mechanisms let person cells to set up good and targeted styles of gene expression that may be gone through telephone divisions with out DNA mutations, thereby developing how diverse heritable styles of gene law keep watch over cellphone differentiation and organogenesis, leading to a different human organism with a number of differing mobile features and tissues.

The paintings starts with simple biology, encompasses equipment, mobile and tissue association, topical concerns in epigenetic evolution and environmental epigenesis, and finally scientific affliction discovery and remedy.

Each hugely illustrated bankruptcy is geared up to in short summarize present learn, offer applicable pedagogical suggestions, pertinent equipment, appropriate version organisms, and medical examples.

  • Reviews present wisdom at the heritable molecular mechanisms that keep an eye on gene expression, give a contribution to affliction susceptibility, and aspect to power therapy in destiny therapies
  • Helps readers know how epigenetic marks are distinct, and to what volume transgenerational epigenetic alterations are instilled and probably handed onto offspring
  • Chapters are replete with medical examples to empower the fundamental biology with translational significance
  • Offers greater than a hundred illustrations to distill key techniques and decipher advanced science

Show description

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Example text

Regression shrinkage and selection via the lasso. J R Stat Soc B 1996;58(1):267–88. [71] Schulz MH, Zerbino DR,Vingron M, Birney E. Oases: robust de novo RNA-seq assembly across the dynamic range of expression levels. Bioinformatics 2012;28(8):1086–92. [72] Frazee AC, Jaffee AE, Langmead B, Leek JT. Polyester: simulating RNA-seq datasets with differential transcript expression. Bioinformatics 2015;31(17):2778–84. Epigenetic gene expression—an introduction [73] Lin MF, Jungreis I, Kellis M. PhyloCSF: a comparative genomics method to distinguish protein coding and non-coding regions.

Bioinformatics 2010;26(7):873–81. [76] Wang K, Singh D, Zeng Z, et al. MapSplice: accurate mapping of RNA-seq reads for splice junction discovery. Nucleic Acids Res 2010;38(18):e178. [77] Behr J, Kahles A, Zhong Y, Sreedharan VT, Drewe P, Ratsch G. MITIE: Simultaneous RNA-Seq-based transcript identification and quantification in multiple samples. Bioinformatics 2013;29(20):2529–38. [78] Dao P, Numanagic I, Lin YY, et al. ORMAN: optimal resolution of ambiguous RNA-Seq multimappings in the presence of novel isoforms.

102] Arnaudo AM, Garcia BA. Proteomic characterization of novel histone post-translational modifications. Epigenet Chromatin 2013;6:24–30. [103] Capell BC, Berger SL. Genome-wide epigenetics. J Invest Dermatol 2013;133(6):e9. [104] Fischle W. Molecular mechanisms of histone modification function. Biochim Biophys Acta 2014;1839(8):621–2. [105] Huang H, Sabari BR, Garcia BA, Allis CD, Zhao Y. SnapShot: histone modifications. Cell 2014;159(2):458–e1. [106] Brehove M, Wang T, North J, et al. Histone core phosphorylation regulates DNA accessibility.

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