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Extra info for Fibrosis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Of past P&F projects, 74% received additional grant support (60%, federal grants) and more than 90% continue involvement in CF research. The Center emphasizes translational research, and the next five year cycle should see the testing of new therapeutic strategies developed in the Center in CF patients. Generate_Screen • Project Title: CORE--ANIMAL MODEL AND DELIVERY Principal Investigator & Institution: Matalon, Sadis; Acting Associate Provost for Research; University of Alabama at Birmingham Uab Station Birmingham, Al 35294 Timing: Fiscal Year 2002; Project Start 01-JAN-2002; Project End 31-DEC-2002 Summary: (Taken directly from the application) Five of the pilot projects in the current application, and ten investigators with funded RO1s or other grants for gene transfer, have indicated a need for assistance with 1) instillation or aerosolization of gene delivery vehicles, 2) detection of reporter transgenes, 3) ion transport measurements in CF mice, or 4) histopathology in order to test safety and biologic effect of gene transfer to mammalian airways.
These studies will focus on determining the requirements of AM apoptosis to signaling T helper cell activation leading to lung fibrosis. Aim 3 will be accomplished by isolating and characterizing the phenotypes of different subpopulations of human AM and examining their functions and responses to silica and asbestos induced apoptosis. The proteins corresponding to the epitopes will be characterized and AM from fibrotic patients will be examined. The importance of the work relates to the large numbers of asbestos and silica exposed individuals, and to the continual exposure of the public to potentially fibrogenic particles in the urban environment.
3. The IL-4 receptor (IL-4Ralpha) signaling pathway in lung cells mediates increased TGF-beta production and lung fibrosis. To test these hypotheses, we propose the following specific aims: 1. In B cell deficient mice, to determine effects of bleomycin or infection of the lungs with MHV68 on lung function, histopathotogy, lung collagen content, Th1 and Th2 lymphocyte responses and cytokine ILL-4, IL-5, IL-13, IFNgamma, TGFbeta) 36 Fibrosis production by whole lung and lung-derived T lymphocytes.