By Lynn B Bailey
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Extra resources for Folate in health and disease
Historical perspective on key advances in the biochemistry and physiology of folates. In: Picciano MF, Stokstad ELR, Gregory JF, eds. Contemporary Issues in Clinical Nutrition. Vol. 13. Folic Acid Metabolism in Health and Disease. New York Wiley-Liss, 199O:l-21. 3. Shane B, Stokstad ELR. Vitamin B,,folate interrelationships. Ann Rev Nutr 1985; 5:115-141. 4. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991; 338:131-137.
The role of folate is, with a few rare exceptions, to carry onecarbon units. These onecarbon units exist at various levels of oxidation. The entire range of oxidation stam for onecatbon compoundsextends from methane, the most reduced, to carbon dioxide, the most oxidized. With the exception of carbon dioxide, onecarbon units are generated in the cell during metabolism andare carried from one reaction to anotheras folate derivatives. The oxidation levels differ from each other by the gain or loss of two electrons.
Folates and pterins. Vol. Nutritional, Pharmacological. and Physiological Aspects. New York: John Wiley & Sons, Lee H-C, Shoda R, Krall JA, FosterJD, Selhub J, Rosenbeny TL. Folate binding protein from kidney brush border membranes contiins components of a glycoinositol phospholipid anchor. Biochemistry Weitman SD, Weinberg Coney LR. Zarawski VR, Jennings DS, Kamen BA. Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis. Cancer Res Kamen BA, Capdevila A.