By Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee, Marie C. McCormick, Theresa M. Wizemann, Donna A. Almario, Kathleen Stratton
With present ideas calling for babies to obtain a number of doses of vaccines in the course of their first 12 months of existence and with unexpected child demise syndrome (SIDS) the main widespread explanation for demise throughout the put up neonatal interval, it is very important reply to matters that vaccination could play a task in unexpected unforeseen youngster demise. The committee reviewed epidemiologic facts targeting 3 results: SIDS, all SUDI (sudden unforeseen loss of life in infancy), and neonatal demise (infant loss of life, even if unexpected or now not, throughout the first four weeks of life). according to this assessment, the committee concluded that the facts favors rejection of a causal dating among a few vaccines and SIDS; and that the facts is insufficient to simply accept or reject a causal courting among different vaccines and SIDS, SUDI, or neonatal loss of life. The proof concerning organic mechanisms is largely theoretical, reflecting in huge degree the inability of information about the pathogenesis of SIDS.
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Extra info for Immunization Safety Review: Vaccinations and Sudden Unexpected Death in Infancy
This provided for an observation period of approximately 3 months following receipt of the first dose. Serious adverse events included hospitalizations; events that were fatal, life threatening, or disabling; congenital abnormalities; or the occurrence of malignancies. Also recorded were severe early onset reactions, such as anaphylaxis, and other symptoms considered serious by investigators. Researchers focused their analysis on SIDS, neurologic events, and hypotonic-hyporesponsive episodes. 23%) serious adverse events were reported for the 67,000 vaccine doses administered during the study period.
Guidelines for Death Scene Investigation of Sudden, Unexplained Infant Deaths: Recommendations of the Interagency Panel on Sudden Infant Death Syndrome. MMWR Morbidity and Mortality Weekly Report 45(RR-10):1–6. Chace D, Naylor E. 2002. Presentation made to Immunization Safety Review Committee on October 28, 2002. Screening for Inborn Errors of Metabolism. Filiano JJ, Kinney HC. 1994. A perspective on neuropathologic findings in victims of the sudden infant death syndrome: The triple-risk model.
Other considerations may include the perceived intensity of public or professional concern, or the feasibility of additional research to help resolve scientific uncertainty regarding causality. The findings of the scientific and significance assessments provide the basis for the committee’s recommendations regarding the public health response to the issue. In particular, the committee addresses needs for a review of immunization policy, for current and future research, and for effective communication strategies.