By Hans-Georg Rammensee
This publication is established on a accomplished record of MHC peptide motifs and ligands as identified up to now, including chosen T telephone epitopes, prepared in an easy-to-read type. this data is placed into context through chapters on MHC gene association, MHC constitution, T phone epitope prediction, antigen processing and T cellphone responses. additionally, the ebook presents loads of complementary info: amino acid sequences of MHC category I alpha1 and alpha2 domain names and of sophistication II alpha1 and beta1 domain names, the verified or envisioned composition and specificity of MHC wallet, notes on MHC nomenclature together with outdated assignments and connection with precious net addresses. A convenient reference guide that are meant to be worthy for all these facing MHC-associated peptides.
Read Online or Download MHC Ligands and Peptide Motifs PDF
Similar anatomy books
Clinical Physiology and Pharmacology
This ebook is an available choice of case examine situations perfect for body structure and pharmacology revision for pharmacy, scientific, biomedical technological know-how, medical technology and healthcare scholars. essentially dependent and arranged through significant organ process, the e-book emphasises ways that key symptoms of illness tell prognosis and the alternative of therapy, including the suitable pharmacological mechanisms.
The Cytoskeleton, Vol. 1: Structure and Assembly
This quantity of the treatise bargains with structural elements of the cytoskeleton: the features of the filaments and their parts; the association of the genes; motor proteins; interactions with membranes.
First published in 1983, this booklet issues the comparative physiological variations of vertebrate animals, specially mammals, to cessation of respiring. those diversifications have been initially pointed out in species residing in aquatic habitats. The argument is gifted that the usual divers demonstrate a well-developed and comfortably studied instance of a extra normal defence opposed to asphyxia.
The Human Brain and Spinal Cord: Functional Neuroanatomy and Dissection Guide
This booklet was once written to serve either as a consultant for the dissection of the human mind and as an illustrated compendium of the sensible anatomy of the mind and spinal twine. during this feel, the publication represents an up to date and multiplied model of the ebook The Human mind and Spinal wire written via the writer and released in Swedish through Scandinavian collage Books in 1961.
- Acquired Speech and Language Disorders: A neuroanatomical and functional neurological approach
- The Science of Drinking: How Alcohol Affects Your Body and Mind
- Pelvic Floor Anatomy and the Surgery of Pulsion Enterocoele
- Cliffs Quick Review Anatomy and Physiology (Cliffs quick review)
- Biosimulation : simulation of living systems
Additional info for MHC Ligands and Peptide Motifs
Example text
Con 't) RA -T -T -T -T -T -T -T -T -T -T -T -T -T -T -T -T -T -T -T til' ~, 0 ~ 1 ;0 0... , ----1-1--- ----S---F- CONSENSUS A*J202 A·JJOl A*JJ02 A*JJOJ A"3fOl A"Jf02 A"J601 A*4JOI A*6601 A·6602 A*660J A*68011 A*68012 A"6B02 A*6BOJ A*690l A"740l A*7402 A*740J A*BOOI A"300S ---------- ---0-0-------S---F- ---Q-D-------S---F- ---Q-D-------S---F- ---Q-D-----------F- ---Q-D-------S---F- ---R-D-----------F- ---R-D-----------F- ---0-0-----------F- ---0-0-----------F- ---0-0-----------F- ---0-0-------S---F- ---R-D-------S---F- ---R-D-----------F- ---H---------S---F- ---R-D-------S-K-F- ---H--------------- ---Q-D------------- ---0-0------------- ---0-0---- HE---W---HE---Q-------------------------------K--------R--------R-------- HE---W---HE---W---- H--------HE---K---HE---K---HE---W---HE---W---HE---W---HE---W---- --R--------R--------R--------R--------R--------L--------R--------R--------R--------R-----------------------------OG------------------------------------------------------------------ -------H--------H--------M--------M--------M--------M--------M-- --------T--------T---K-----V --------T--------T--------T--------T- HE---K---HE-------HA---R-V-HE---W---HE---W---HE---W---- ---------------------------------------------- -T -T -T -T -T -T ---------- ---------- -T --------------------R--------R--------E------- ---------- -T ---------- -T -T -T -T -T -T - ------K--- -------H-- -T-KH----- H----W---- ---------- ---------- -T ------K--- -------M-- -T-KH----- H----W---- ---------- ---------- -T ------K--- -------M-- -T-KH----- H--------- ---------- ---------- -T ---------- -------M-- ---------- ---------- ---------- ---- ______ -T ---------- -------M-- ---------- ---------- ---------- ---------- -T ---------- -------M-- ---------- ---------- ---------- ---------- -T ---------- -------M-- ---K------ -R-------- --E--OG--- ---------- -T HE---W---- --E------- -------~-------K--- -------M-- -T-KH----- H----W---- ---------- ---------- -T ------K--- -------M-- -T-KH----- H----W---- ---------- ---------- -T ---------------------------------------------------------------- -------M-- ----------------H----------- ---- --H- - •.
819 ,820 This genetic region represents the first instance when MHC class I and class II genes have been shown to be linked outside of the MHC proper. The organization of DNA elements regulating avian class II B genes differs from 31 that in mammalian species, though the S, X and Yboxes are well conserved in sequence and location. 821 The MHC class II DB genes of the rednecked wallaby (Macropus rufogriseus),822 belong to new families that are not orthologous to eutherian DB families. This indicates the possibility that the DB genes of marsupials have an ancestor different from the DB gene ancestors of mammals.
It is a 200 kD serum protein synthesized as a single precursor molecule, the mature protein has three domains-a, ~, y-of 75,95 and 30 kD, respectively. , upon activation by the Cl component C4 activates another member of the complement cascade (C2). The C4A component binds efficiently to proteins in antigen-antibody complexes and thus facilitates their solubilization and clearance, the C4B component binds preferentially to cell surfaces and thus participates in celllysis, The C4A and C4B proteins are encoded in two separate loci which are members of a family that includes two other complementencoding loci C3 and C5, as well as the a2-macroglobulin gene.