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Indd 19 6/7/2011 7:11:15 PM 20 METHODOLOGICAL CONSIDERATIONS left goal-box and one that led to a right goal-box. Another single-choice maze is the Y-maze in which the alleys to the goal box met the stem at a 45° angle instead of a 90° angle as in the T-maze. , see 1–8]. Subjects, divided into two groups to control for position preference, learn to turn to the left after their dose of training drug and to turn to the right after vehicle; these conditions were reversed for the second group. ). , win, stay– lose, shift behavior).
Hence, when an ED50 dose is provided for the training drug, the training dose of the training drug must also be specified. Once animals are trained to discriminate a specific dose of training drug from vehicle, two general types of experiments can be performed: 1) tests of stimulus generalization (“substitution”) and 2) tests of stimulus antagonism (“blockade”). Tests of stimulus generalization are employed to determine the similarity of the stimulus effects produced by a challenge drug (or “test drug”) to those produced by the training drug.
Negative reinforcement is sometimes mistaken for punishment. That error is perhaps not unexpected because an often-used synonym for positive reinforcement is reward, which may lead to the conclusion that because the terms positive and negative are opposite, then it must follow that the opposite of reward is punishment. However the terms positive and negative, in reinforcement vocabulary, do not refer to something “good” and “bad” but to the presence versus removal, respectively, of an event that follows behavior.