By Ulf Schmitz, Olaf Wolkenhauer
This quantity courses readers during the box of platforms drugs by way of defining the terminology, and describing how proven computational tools shape bioinformatics and platforms biology might be taken ahead to an integrative structures medication process. Chapters supply an outlook at the position that platforms medication may possibly or should still play in numerous clinical fields, and describe various points of the platforms medication strategy in motion. finally it introduces instruments, assets and methodologies from bioinformatics and structures biology, and the way to use those in a platforms medication undertaking. Written for the tools in Molecular Biology sequence, chapters comprise introductions to their respective themes, and speak about experimental and computational ways, tools, and instruments that are supposed to be thought of for a winning platforms medication undertaking. Systems Medicine goals to inspire and supply assistance for collaborations throughout disciplines to take on present day demanding situations regarding human healthiness and overall healthiness.
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Extra resources for Systems Medicine
Buchel F, Rodriguez N, Swainston N et al (2013) Path2Models: large-scale generation of computational models from biochemical pathway maps. BMC Syst Biol 7:116 29. Wrzodek C, Buchel F, Ruff M et al (2013) Precise generation of systems biology models from KEGG pathways. BMC Syst Biol 7:15 30. Bader GD, Cary MP, Sander C (2006) Pathguide: a pathway resource list. Nucleic Acids Res 34(Database issue):D504–D506 31. Cerami EG, Gross BE, Demir E et al (2011) Pathway Commons, a web resource for biological pathway data.
Shaw DR (2009) Searching the Mouse Genome Informatics (MGI) resources for information on mouse biology from genotype to phenotype. Curr Protoc Bioinformatics. Chapter 1:Unit1 7 44. Nam D, Kim SY (2008) Gene-set approach for expression pattern analysis. Brief Bioinform 9(3):189–197 45. Levine AJ, Miller JA, Shapshak P et al (2013) Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease. BMC Med Genomics 6:4 46.
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