The Somatotrophic Axis in Brain Function by Fred Nyberg

By Fred Nyberg

The somatotropic axis is without doubt one of the significant hormonal structures regulating postnatal development in mammals. It interacts with the primary frightened procedure on a number of degrees. progress hormone (GH) and insulin-like progress factor-I (IGF-I) receptors are expressed in lots of mind parts together with the hippocampus, pituitary and hypothalamus. GH and IGF-I are vital components within the improvement and differentiation of the CNS and feature protecting houses in dementia, in addition to in disturbing and ischaemic harm of the CNS. additionally GH has an immense influence on temper and future health with GH secretory means being decreased in depression.This quantity will contain chapters (1) on easy wisdom on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors within the CNS, together with blood mind barrier shipping of either hormones, (3) on activities of the 2 hormones on CNS functionality (basic science), (4) on medical points of GH/IGF-1 relating to numerous CNS features and problems, and eventually (5) on a few destiny views during this region of technological know-how. Contents are good balanced and canopy a number of correct themes from uncomplicated to medical researchInternational choice of authors, with a very good illustration of the examine on development hormonesA well timed e-book so that it will be important to scientists in either easy and medical learn

Show description

By Fred Nyberg

The somatotropic axis is without doubt one of the significant hormonal structures regulating postnatal development in mammals. It interacts with the primary frightened procedure on a number of degrees. progress hormone (GH) and insulin-like progress factor-I (IGF-I) receptors are expressed in lots of mind parts together with the hippocampus, pituitary and hypothalamus. GH and IGF-I are vital components within the improvement and differentiation of the CNS and feature protecting houses in dementia, in addition to in disturbing and ischaemic harm of the CNS. additionally GH has an immense influence on temper and future health with GH secretory means being decreased in depression.This quantity will contain chapters (1) on easy wisdom on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors within the CNS, together with blood mind barrier shipping of either hormones, (3) on activities of the 2 hormones on CNS functionality (basic science), (4) on medical points of GH/IGF-1 relating to numerous CNS features and problems, and eventually (5) on a few destiny views during this region of technological know-how. Contents are good balanced and canopy a number of correct themes from uncomplicated to medical researchInternational choice of authors, with a very good illustration of the examine on development hormonesA well timed e-book so that it will be important to scientists in either easy and medical learn

Show description

Read or Download The Somatotrophic Axis in Brain Function PDF

Similar anatomy books

Clinical Physiology and Pharmacology

This ebook is an available choice of case research situations excellent for body structure and pharmacology revision for pharmacy, scientific, biomedical technology, medical technological know-how and healthcare scholars. truly established and arranged by way of significant organ process, the publication emphasises ways that key symptoms of ailment tell prognosis and the alternative of remedy, including the proper pharmacological mechanisms.

The Cytoskeleton, Vol. 1: Structure and Assembly

This quantity of the treatise bargains with structural points of the cytoskeleton: the features of the filaments and their parts; the association of the genes; motor proteins; interactions with membranes.

Diving and Asphyxia: A Comparative Study of Animals and Man (Monographs of the Physiological Society)

First revealed in 1983, this publication matters the comparative physiological variations of vertebrate animals, specially mammals, to cessation of respiring. those variations have been initially pointed out in species dwelling in aquatic habitats. The argument is gifted that the usual divers show a well-developed and comfortably studied instance of a extra basic defence opposed to asphyxia.

The Human Brain and Spinal Cord: Functional Neuroanatomy and Dissection Guide

This publication was once written to serve either as a consultant for the dissection of the human mind and as an illustrated compendium of the practical anatomy of the mind and spinal wire. during this experience, the e-book represents an up-to-date and multiplied model of the e-book The Human mind and Spinal twine written through the writer and released in Swedish through Scandinavian college Books in 1961.

Extra info for The Somatotrophic Axis in Brain Function

Example text

C. (1988). Growth hormone (GH) secretion in the conscious rat: Negative feedback of GH on its own release. J. Endocrinol. 119, 201–209. , and Muller, E. E. (1999). Leptin regulates GH secretion in the rat by acting on GHRH and somatostatinergic functions. J. Endocrinol. 162, 95–99. , and Muller E. E. (1993). Growth hormone secretion is differentially affected in genetically obese male and female rats. Neuroendocrinology 57, 928–934. Cunha, S. , and Mayo, K. E. (2002). Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced cyclic adenosine 3Ј,5Ј-monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors.

Invest. 19, 542–547. , Rowe, E. , Scanes, C. , Anderson, L. , and Jeftinija, S. (2004). Effects of leptin on intracellular calcium concentrations in isolated porcine somatotropes. Neuroendocrinology 80, 73–82. , and Nikolics, K. (1992). A role for IGF-I in the rescue of CNS neurons following hypoxicischemic injury. Biochem. Biophys. Res. Commun. 182, 593–599. Grant, M. , Mames, R. , Ellis, E. , and Guy, J. (1993). Insulin-like growth factor-I acts as an angiogenic 1. Regulation and Mechanism of GH and IGF-I agent in rabbit cornea and retina: Comparative studies with basic fibroblast growth factor.

Insulin-like growth factor-I action on rat anterior pituitary cells: Suppression of growth hormone secretion and messenger ribonucleic acid levels. Endocrinology 118, 176–182. , and Melmed, S. (1987). Insulin-like growth factor-I regulation of growth hormone gene transcription in primary rat pituitary cells. J Clin. Invest. 79, 449–452. , and Melmed, S. (1986). Insulin-like growth factor-I regulates growth hormone secretion and messenger ribonucleic acid levels in human pituitary tumor cells. J.

Download PDF sample

Rated 4.23 of 5 – based on 41 votes