By R. D. Sinelnikov and Ludmila Aksenova
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Additional info for Atlas of Human Anatomy vol.III-Nervous System, Endocrine Glands And Sense Organs
The characteristic cytoplasmic marker, the Birbeck granule, is seen ultrastructurally in 10-week-old embryos (12). The expression of a more characteristic immunohistochemical marker, CD1a, is completed by 12 to 13 weeks of estimated gestational age (12,13). Merkel cells can also be seen in the epidermis of 8- to 10-week-old embryos. The origin of Merkel cells is debatable. Some have suggested a neural crest derivation (14), whereas others suggest epidermal origin through a process of differentiation from neighboring keratinocytes (15,16,17).
Gallagher and Allard C. van der Wal SECTION IV Nervous System 10 Peripheral Nervous System Carlos Ortiz-Hidalgo and Roy O. Weller 11 Central Nervous System Gregory N. Fuller and Peter C. Burger 12 Pituitary and Sellar Region M. Beatriz, S. Lopes, Peter J. Pernicone, Bernd W. Scheithauer, Eva Horvath, and Kalman Kovacs SECTION V Head and Neck 13 Normal Eye and Ocular Adnexa Gordon K. Klintworth and Thomas J. Cummings 14 The Ear and Temporal Bone Bruce M. Wenig and Leslie Michaels 15 Mouth, Nose, and Paranasal Sinuses Liron Pantanowitz and Karoly Balogh 16 Larynx and Pharynx Stacey E.
Basement Membrane Zone The basement membrane zone separates the epidermal basal layer from the dermis. 6). By electron microscopy, the basal cells are attached to the basal lamina by hemidesmosomes. 7 Ultrastructure of basement membrane (×37,800) (1, hemidesmosome; 2, lamina lucida; 3, lamina densa; 4, lamina reticularis; 5, melanin; 6, tonofilaments). 6 PAS-positive basement membrane. 1. The plasma membrane of the basal cells containing the hemidesmosomes. Bullous pemphigoid antigen 1 is localized in the intracellular component of hemidesmosomes.