Chapter 1 Chairman's commencing comments (pages 1–4): L. J. Witts
Chapter 2 On Leuk?mia study (pages 5–12): J. Engelbreth?Holm
Chapter three healing Correlation among Mouse and Human Leuk?mia (pages 13–25): Joseph H. Burchenal
Chapter four The Shortcomings of Animal study in Leuk?mia (pages 26–37): M. C. G. Israels
Chapter five the concept that of Conditioned and self sufficient Neoplasms (pages 38–44): J. Furth
Chapter 6 the strategy of Quantitative selection of chicken Leuk?mia Virus (pages 45–51): Astrid Fagraeus
Chapter 7 stories at the Endocellular Distribution of the Transmissible poultry Leuk?mia Virus (pages 52–60): Bo Thorell
Chapter eight a few Experimental Observations on a pressure of Transmissible Aleuk?mic Leuk?mia (RPL 12 Lymphoid Tumour) (pages 61–75): C. le Q. Darcel and G. Negroni
Chapter nine Transmissible Mouse Leuk?mia: organic houses of the Mouse Leuk?mia Agent (pages 76–104): Ludwik Gross
Chapter 10 The Phenomena of Resistance and Dependence in Leuk?mic Cells (pages 105–129): L. W. Law
Chapter eleven Leuk?mic kinds of the Murray?Begg Endothelioma (pages 130–133): Charles Oberling
Chapter 12 Respective Values of Electron and Phase?Contrast Microscopy within the research of the Leuk?mic mobile (pages 134–145): A. Lacassagne and M. Bessis
Chapter thirteen Induction of Leuk?mia via Ionizing Irradiation (pages 146–161): J. Furth and A. C. Upton
Chapter 14 reviews at the amendment of Radiation damage (pages 162–188): L. O. Jacobson, E. okay. Marks, E. O. Gaston and E. L. Simmons
Chapter 15 The function of Bone Marrow and Spleen in prompted and Spontaneous Lymphatic Leuk?mia (pages 189–195): Egon Lorenz, L. W. legislation and Charles C. Congdon
Chapter sixteen Experimental and medical facets of the motion of varied Carboxylic Acid Derivatives within the fragrant Nitrogen Mustard sequence (pages 196–204): A. Haddow
Chapter 17 scientific event with Myleran remedy, specially in Myeloid Leuk?mia (pages 205–215): Poul Bjerre Hansen
Chapter 18 a brand new Colchicine spinoff (Demecolcin Ciba) as a Cytostatic Agent in Myelogenous Leuk?mia (pages 216–230): S. Moeschlin, H. Meyer and A. Lichtman
Chapter 19 The influence of 1:3?Bis (Ethyleneimino Sulphonyl) Propane in Animal Tumours and Human Leuk?mia (pages 231–243): Edith Paterson and P. B. Kunkler
Chapter 20 The Growth?Inhibiting motion of Mitotic Poisons in Experimental and Human Leuk?mias (pages 244–262): P. Dustin
Chapter 21 The Designing of Selective medicines (pages 263–290): J. F. Danielli
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Now, part of the point of this conference, as I understand it, is to consider not only scientific data but matters of research policy for the future. Recently I have made a study of the finance of this kind of research in this and other countries. I have come to t h e conclusion that while it may appear that a lot of money has been spent in these directions, it has in fact been on an almost microscopical scale, and I think we must recast our ideas as to the vigour and scale on which research has got to be conducted, if we are to produce any decisive or even practically useful contribution in medicine.
In transmitted mouse leukaemia the cells remain fixed in type, but tissue culture methods applied to human acute leukaemias show that these cells are not fixed in type. My original idea was to obtain tissue cultures of human leukaemic leucocytes from bone marrow so that their properties could be thoroughly studied. Although I was careful to choose patients whose marrow contained predominantly primitive cells-say myeloblasts with no detectable myelocytes on the smears-I always ended up with a culture containing myelocytes and not myeloblasts, so I could no longer be sure that the cells differed from normal (Israels, 1940).
1954). Bull. N . Y . Acad. Med. In press. [Discussion of this paper was postponed until after the paper by Dr. ] LE lJKA5MIA RESEARCH G. E. W. WOLSTENHOLME & MARGARET P. CAMERON Copyright 0 1954 Ciba Foundation THE SHORTCOMINGS OF ANIMAL RESEARCH I N LEUKAMIA M . C. G. ISRAELS ANY clinician who works in a department mainly interested in blood diseases has become conscious of the increasing frequency in his clinics of patients suffering from leukaemia. Part of this increase is undoubtedly due to better diagnostic methods; many cases formerly dismissed as “refractory anaemia” or “aplastic or aregenerative anaemia” will nowadays, after fuller investigation, be classified as leukaemia.