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Extra info for Endometriosis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
In the first year we have accumulated significant basic and clinical data in support of our hypothesis that a significant oxidative stress occurs in women with endometriosis. Recruitment for Aim 1 is complete and the data is being analyzed. Recruitment is underway for Aims 2,3. We have used RU486 as a biologic probe to 28 Endometriosis study the in vivo regulation of endometrium and leiomyoma seen with low dose, in vivo. Preliminary data, has shown that leiomyoma and myometrium immunostain for glycodelin.
The proposed rat model of Crohn's disease has been extensively used to study the pathophysiology of this disease. The rat model of intestinal endometriosis wil specfically address the pathopysiological role of TNF/TNFR expression in the implantation of ectopic endometrium in the intestine. The specific aims of the proposed plan are to: 1)determine the TNF'-aipha mRNA and protein expression in the implants, intestine, and peritoneal fluid in a rat model of intestinal endometriosis and compare with the rat model of Crohn's disease 2) determine the expression on TNF receptors (TNFR1/TNFR2) in the endometrial implants and associated intestine in a rat model of intestinal endometriosis and compare with the rat model of Crohn's disease 3) determine the expression of tumor necrosis factor receptor-associated factors (TRAFs) in both animals models and, 4) establish a specific pathophysiological role of TNF/TNFR signaling for the rat model of intestinal endometriosis and the rat model of Crohn's disease.
Our overall goal is to develop new information that will lead to effective strategies for preventing osteoporosis-related fractures among the elderly. This project contributes by demonstrating the public health importance of specific risk factors and, by identifying high risk groups within each cohort, allowing future control programs to be designed and conducted more efficiently. ; Emory University 1784 North Decatur Road Atlanta, Ga 30322 Timing: Fiscal Year 2001 Summary: There is no text on file for this abstract.