Functional Glycomics by Minoru Fukuda

By Minoru Fukuda

Some time past decade, there was an explosion of development in figuring out the jobs of carbohydrates in organic platforms. This explosive growth used to be made with the efforts in selecting the jobs of carbohydrates in immunology, neurobiology and lots of different disciplines, interpreting each one targeted procedure and using new expertise. This quantity represents the second one of 3 within the tools in Enzymology sequence, together with Glycobiology (vol. 415) and Glycomics (vol. 416), devoted to disseminating info on equipment in settling on the organic roles of carbohydrates. those books are designed to supply an creation of latest tips on how to a wide number of readers who wish to perform and give a contribution to the development of glycobiology. The tools lined comprise structural research of carbohydrates, organic and chemical synthesis of carbohydrates, expression and resolution of ligands for carbohydrate-binding proteins, gene expression profiling together with micro array, and iteration of gene knockout mice and their phenotype analyses.

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By Minoru Fukuda

Some time past decade, there was an explosion of development in figuring out the jobs of carbohydrates in organic platforms. This explosive growth used to be made with the efforts in selecting the jobs of carbohydrates in immunology, neurobiology and lots of different disciplines, interpreting each one targeted procedure and using new expertise. This quantity represents the second one of 3 within the tools in Enzymology sequence, together with Glycobiology (vol. 415) and Glycomics (vol. 416), devoted to disseminating info on equipment in settling on the organic roles of carbohydrates. those books are designed to supply an creation of latest tips on how to a wide number of readers who wish to perform and give a contribution to the development of glycobiology. The tools lined comprise structural research of carbohydrates, organic and chemical synthesis of carbohydrates, expression and resolution of ligands for carbohydrate-binding proteins, gene expression profiling together with micro array, and iteration of gene knockout mice and their phenotype analyses.

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Biophys. Acta. 1573, 388–393. , Muller, W. , and Dennis, J. W. (2000). Suppression of tumor growth and metastasis in Mgat5‐deficient mice. Nat. Med. 6, 306–312. Haltiwanger, R. , and Lowe, J. B. (2004). Role of glycosylation in development. Annu. Rev. Biochem. 73, 491–537. , and Taniguchi, N. (1996). Transcriptional regulation of the N‐acetylglucosaminyltransferase V gene in human bile duct carcinoma cells (HuCC‐T1) is mediated by Ets‐1. J. Biol. Chem. 271, 26706–26712. Lowe, J. , and Marth, J.

6, 306–312. Haltiwanger, R. , and Lowe, J. B. (2004). Role of glycosylation in development. Annu. Rev. Biochem. 73, 491–537. , and Taniguchi, N. (1996). Transcriptional regulation of the N‐acetylglucosaminyltransferase V gene in human bile duct carcinoma cells (HuCC‐T1) is mediated by Ets‐1. J. Biol. Chem. 271, 26706–26712. Lowe, J. , and Marth, J. D. (2003). A genetic approach to Mammalian glycan function. Annu. Rev. Biochem. 72, 643–691. , Hoodless, P. , and Wrana, J. L. (1996). MADR2 is a substrate of the TGF‐beta receptor and its phosphorylation is required for nuclear accumulation and signaling.

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