By The British Nutrition Foundation
Iron is a key aspect in meals. It has a relevant position in power metabolism of dwelling cells and iron deficiency anaemia is likely one of the world's commonest dietary deficiency illnesses. The Iron job strength is a committee of stated specialists within the box of iron biochemistry and metabolism. The participants have been invited via the British foodstuff beginning to study the present kingdom of data of the dietary and physiological importance of this most crucial aspect. Iron: dietary and physiological importance is a radical evaluation of the topic through experts.
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Extra resources for Iron: Nutritional and physiological significance The Report of the British Nutrition Foundation’s Task Force
Sample text
1 Use in population surveys Factors other than variation in iron stores which might influence the analyses should always be considered. In older people there may be a higher incidence of chronic disease and in some parts of Overall variability of assays for iron status (within-subject, day-to-day CV for healthy subjects) Reference Dawkins et al. (1979) Gallagher et al. (1989) Statland and Winkel (1977) Statland et al. (1976) Statland et al. (1977) Pilon et al. (1981) Romslo and Talstad (1988)' Borel et al.
1993) but otherwise vary little with age in adult life. , 1993; Yip, 1994) in compensation for reduced oxygen capacity due to the formation of carboxyhaemoglobin. The investigation of anaemia begins with the blood count in order to distinguish between anaemia due to inadequate supply of iron or, more rarely, to B12 or folate deficiency. Modern automated cell counters provide a rapid and sophisticated way of detecting the changes in red cells which accompany a reduced supply of iron to the bone marrow (Williams, 1990): a low mean cell volume (MCV), a low mean cell haemoglobin concentration (MCH) and a high red cell distribution width (ROW).
1993). 9 Non invasive methods for determining tissue iron concentrations Dual-energy computed tomography, magnetic susceptibility and magnetic resonance imaging are all being exploited but at present are only applicable to the detection of iron overload (Stark, 1991). 3 METHODOLOGICAL AND BIOLOGICAL VARIABIUTY OF ASSAYS The blood assays vary greatly in both methodological and biological stability. 5). Automated cell counters analyse at least 10 000 cells and thus reduce errors. The more complicated procedures involved in immunoassays mean higher methodological variation for ferritin assays (coefficient of variation, CV, of at least 5%) and this, coupled with some physiological variation, gives an overall CV for serum ferritin for an individual over a period of weeks of the order of 15%.