By Adolfo Gustavo Sadile (auth.), Paul R. Sanberg, Klaus-Peter Ossenkopp, Martin Kavaliers (eds.)
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Additional info for Motor Activity and Movement Disorders: Research Issues and Applications
100 ~~~~~ NORMAL POSTNATAL GROWTH o Fig. 6. Maturation of LTH during postnatal life: effect of altered body and brain growth. , corner-crossings + rea rings per 1-min blocks, are reported as cumulative and differential form for rats reared under normal conditions (middle panel), or with decelerated postnatal body and brain growth (lower panel), or perinatal hypothyroidism (upper panel) on d 1 (closed symbols) and 2 (open symbols). Different groups were tested at the biological age of 2, 4, 6, 9, 12, or 15 d after eyelid opening with a transversal design.
0, or 24 h thereafter. Rats exposed for the first time to the maze showed NADPH-d activity in the dorsal hippocampus (granule cells, few hilar neurons, and some CAl pyramidal cells), the caudate-putamen complex, the cerebellum, and all layers of somatosensory cortex, compared to unexposed controls. The positivity was time-dependent since it was present by 2 hand decreased significantly by 24 h. Further, it was impaired by pretreatment with the NMDA receptor antagonist CPP (5 mg/kg) or the NOS inhibitor N6-nitro-L-arginine (L-NOARG; 10 mg/kg).
1978b); 2. , 1993); and 3. , 1994). Thus, there are several components of activity that undergo habituation and several mechanisms by which the animal habituates. Different Strategies Different strategies can be followed to investigate the mechanisms involved in the formation of LTH and its neural substrates, and to validate this plasticity phenomenon as a model for more complex forms of learning and memory processes. Noninterference Studies Noninterference studies can be carried out both in the young and adult rat, provided a Lat-maze of appropriate size is used.