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Degree. C. The specific details of how the crystallization is performed are not disclosed. S. 9 Applications are patent requests which have yet to be granted. ) The following patent applications have been filed since December 2000 relating to Ambien: · Zolpidem hemitartrate Inventor(s): Aronhime, Judith; (Rechovot, IL), Leonov, David; (Rechovot, IL), MeszarosSos, Erzebet; (Debrecen, HU), Salyi, Szaboles; (Debrecen, HU), Szabo, Csaba; (Debrecen, HU), Zavurov, Shlomo; (Lod, IL) Correspondence: KENYON & KENYON; ONE BROADWAY; NEW YORK; NY; 10004; US Patent Application Number: 20020077332 Date filed: April 24, 2001 Abstract: The present invention provides for novel polymorphs of zolpidem hemitartrate and the preparation of the polymorphs.
Author(s): National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland. Source: Meririnne, E Kankaanpaa, A Lillsunde, P Seppala, T Pharmacol-BiochemBehavolume 1999 January; 62(1): 159-64 0091-3057 · Zinc and zolpidem modulate mIPSCs in rat neocortical pyramidal neurons. Author(s): Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. Source: Defazio, T Hablitz, J J J-Neurophysiol. 1998 October; 80(4): 1670-7 0022-3077 · Zolpidem 10 mg given at daytime is not antagonized by 300 mg caffeine in man.
Zolpidem is a suitable short acting hypnotic for the controlled-release dosage form according to the present invention. Zolpidem is a hypnotic from the therapeutical class of imidazopyridines. It is administrated orally by means of a tablet or other solid dosage form. Zolpidem acts rapidly. Indeed pharmacokinetic and pharmacodynamic data show that zolpidem has both a rapid absorption and onset of hypnotic action. 4 hours and a duration of action of up to 6 hours. For reasons of simplicity, in the absence of contrary indication, within the whole description "zolpidem" or the "drug" means zolpidem per se as well as its salts.