By Sybille Mazurek, Maria Shoshan
The 4 sections of this booklet conceal cellphone and molecular biology of tumor metabolism, metabolites, tumor microenvironment, diagnostics and epigenetics. Written via foreign specialists, it presents a radical perception into and realizing of tumor mobile metabolism and its position in tumor biology. The e-book is meant for scientists in melanoma mobilephone and molecular biology, scientists in drug and diagnostic improvement, in addition to for clinicians and oncologists.
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Extra info for Tumor Cell Metabolism: Pathways, Regulation and Biology
In this context, considerable genetic heterogeneity is seen within a particular tumor and between tumors within an individual (Shah et al. 2009; Yancovitz et al. 2012; Burrell et al. 2013), and this heterogeneity would be expected to be associated with epigenetic heterogeneity. However, little attention has been paid to the epigenetic complexity of individual tumors. Epigenetic changes are mediated through a range of epigenetic modifiers including DNA methyltransferases, histone methyltransferases, histone demethylases, histone acetyltransferases, and histone deacetylases.
2009; Shyh-Chang et al. 2013), whereas MSCs continue to consume O2 at a high rate when transferred to normoxic conditions (Pattappa et al. 2011). Consequently, aerobic glycolysis in proliferating cells in mature organisms may be a consequence of sustained hypoxia during early development resulting in cellular bioenergetics being remodeled towards glycolytic metabolism regardless of whether oxygen is present or not. In general, quiescent stem cells and differentiated cells employ OXPHOS, while non-quiescent pluripotent and embryonic stem cells, progenitor cells, and myoblasts are highly glycolytic and use OXPHOS to varying degrees.
2011). These cells are characterized by low mitochondrial mass and immature internal cristae (Chung et al. 2007). Nevertheless, other hemopoietic stem cell populations reside in well-oxygenated perivascular regions of the bone marrow and move between these two distinct niches and into the highly oxygenated peripheral circulation. Whether this movement between niches and the circulation is associated with changes in the balance between glycolytic and mitochondrial metabolism or is characterized by glycolysis regardless of oxygen tension (aerobic glycolysis) warrants further investigation.