By Institute of Medicine, Board on the Health of Select Populations, Committee on the Review of the Appropriate Use of AFIP's Tissue Repository Following Its Transfer to the Joint Pathology Center
Based throughout the Civil warfare because the military scientific Museum, the militia Institute of Pathology (AFIP) collected the world's biggest selection of human pathologic specimens and used to be thought of a optimal session, schooling, and study facility by way of the top of the 20 th century. Samples from the AFIP have been instrumental in supporting to unravel public health and wellbeing mysteries, reminiscent of the series of the genome of the 1918 influenza virus that killed greater than forty million humans world wide.
In 2005, the federal Base Realignment and Closure fee suggested that the AFIP be closed, and its biorepository used to be transferred to the newly created Joint Pathology heart. in the course of the transition, the dept of safety requested the IOM to supply recommendation on working the biorepository, dealing with its assortment, and picking acceptable destiny use of specimens for session, schooling, and learn.
Future makes use of of the dep. of safety Joint Pathology middle Biorepository, the IOM proposes a chain of protocols, criteria, safeguards, and directions which may aid to make sure that this nationwide treasure remains to be on hand to researchers within the years yet to come, whereas keeping the privateness of the folk who supplied the fabrics and keeping the safety in their own information.
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Additional info for Future Uses of the Department of Defense Joint Pathology Center Biorepository
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The DoD later formed a working group that developed a concept of operations for the organization. It defined the JPC’s vision and mission as follows (JPC, 2012): Vision: The Joint Pathology Center (JPC) is the federal government’s premier pathology reference center supporting the Military Health System (MHS), DoD and other federal agencies. PREPUBLICATION COPY: UNCORRECTED PROOFS Copyright © National Academy of Sciences. All rights reserved. Future Uses of the Department of Defense Joint Pathology Center Biorepository 1-4 FUTURE USES OF THE DOD JOINT PATHOLOGY CENTER BIOREPOSITORY Mission: The JPC provides world class diagnostic subspecialty pathology consultation, education and research services to federal agencies and operates the National Pathology Tissue Repository in support of the mission of the Department of Defense and other federal agencies.
S. Army 17 Uniformed Services University of the Health Sciences (USUHS) 13 multi-agency collaboration (all Federal agencies) 11 civilian academic universities 4 private sector pharmaceutical or medical device companies 3 civilian hospitals ORIGIN OF THE STUDY AND STATEMENT OF TASK The DoD in 2010 asked IOM to conduct a study of the appropriate use of the biospecimens to be maintained by the JPC. It noted that the mission of the center includes support of two primary collections—the pathology material accumulated by AFIP in the course of its clinical, education, and research activities (the Central Collection) and pathology material from DoD military treatment facilities closed under the BRAC program (the BRAC Collection)—and other materials, such as the war and cohort registries (Baker, 2011).
Specimen water (about 70 percent of tissue mass) is replaced with paraffin wax, and the specimen is surrounded by paraffin in a mold to provide support during sectioning and to aid in preservation. Formalin-fixed paraffin-embedded (FFPE) tissue is one of the predominant forms in which pathologic specimens are stored. Sectioning. Sections are cut on a microtome, which has a blade similar to a single-edge razor blade, that is advanced through a block of paraffin-embedded tissue. The shavings—about 5 µm thick, about twice the thickness of a human hair—are placed in water, and the floating shavings are picked up on 1 × 3-in.