Progress in Drug Research / Fortschritte der by David R. Webb, Vijendra KR. Singh, H. Hugh Fudenberg, Roger

By David R. Webb, Vijendra KR. Singh, H. Hugh Fudenberg, Roger W. Russell, L. Öhman, G. Maluszynska, K.-E. MAgnusson, O. Stendahl, Peter A. Lambert, David H. P. Streeten, Gunnar H. Anderson Jr, Vickram Ramkumar, George Pierson, Gary L. Stiles, Bernard Testa,

In the 1st years of the lifestyles of this sequence of monographs, throughout the so-called "Golden Age" of drug study, the vast majority of the pa­ pers released have been as a rule serious about the conventional domain names of drug learn, particularly chemistry, pharmacology, toxicology and pre­ medical investigations. The sequence' target was once to provide insurance to impor­ tant components of analysis, to introduce new lively ingredients with thera­ peutic capability and to name realization to unsolved difficulties. This goal has no longer replaced. The desk of contents of the current quantity makes obvious, even though, that the quest for brand spanking new medicinal drugs has develop into more and more complicated, and extra, new disciplines have entered the study area. The sequence now comprises stories on bio­ chemical, organic, immunological, physiological and medicinal features of drug study. Researchers actively engaged within the a number of medical fields forming the entity of drug examine can enjoy the wealth of data and adventure of the respective authors, and should be assisted of their endeavour to find new pharmaceutical brokers. these easily desirous to preserve abreast of recent advancements within the advanced, multi-discipline technological know-how can flip to the "Progress in Drug learn" volumes as a nearly encyclopaedic resource of data with no need to refer to the innumerable unique courses. quantity 32 comprises 12 reports, an issue index, an index for the as regards to four hundred articles released within the sequence to date, and an writer and titles index for all 32 volumes.

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By David R. Webb, Vijendra KR. Singh, H. Hugh Fudenberg, Roger W. Russell, L. Öhman, G. Maluszynska, K.-E. MAgnusson, O. Stendahl, Peter A. Lambert, David H. P. Streeten, Gunnar H. Anderson Jr, Vickram Ramkumar, George Pierson, Gary L. Stiles, Bernard Testa,

In the 1st years of the lifestyles of this sequence of monographs, throughout the so-called "Golden Age" of drug study, the vast majority of the pa­ pers released have been as a rule serious about the conventional domain names of drug learn, particularly chemistry, pharmacology, toxicology and pre­ medical investigations. The sequence' target was once to provide insurance to impor­ tant components of analysis, to introduce new lively ingredients with thera­ peutic capability and to name realization to unsolved difficulties. This goal has no longer replaced. The desk of contents of the current quantity makes obvious, even though, that the quest for brand spanking new medicinal drugs has develop into more and more complicated, and extra, new disciplines have entered the study area. The sequence now comprises stories on bio­ chemical, organic, immunological, physiological and medicinal features of drug study. Researchers actively engaged within the a number of medical fields forming the entity of drug examine can enjoy the wealth of data and adventure of the respective authors, and should be assisted of their endeavour to find new pharmaceutical brokers. these easily desirous to preserve abreast of recent advancements within the advanced, multi-discipline technological know-how can flip to the "Progress in Drug learn" volumes as a nearly encyclopaedic resource of data with no need to refer to the innumerable unique courses. quantity 32 comprises 12 reports, an issue index, an index for the as regards to four hundred articles released within the sequence to date, and an writer and titles index for all 32 volumes.

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Masur, N. S. Sharpless, P. A. Fuld and P. Davies: Prog. Neuropsychopharmac. BioI. Psychiatr. 10,627 (1986). W. K. Summers, L. V. Majovski, G. M. Marsh, K. Tachiki and A. Kling: New Engl. J. Med. 315,1241 (1986). 42 Vijendra K~ Singh and H. Hugh Fudenberg J. L. Marx: Science 238, 1041 (1987) Editorial. J. P. Moreau and F. V. DeFeudis: Life Sci. 40,419 (\987). F. S. Abuzzahad, G. E. Merwin, R. L. Zimmerman and M. C. Sherman: Pharmakopsychiatr. 10, 49 (\ 977). 98 C. Wilsher, G. Atkins and P. Manfield: Psychopharmacology 65, 107 (\979).

McGillis, B. L. Spangelo and A. L. Goldstein: J. Immun. 135. 806s (1985). R. Ader and M. Cohen: Psychos om. Med. 37. 333 (1975). D. Felton, S. Y. Felton, S. L. Carlton, J. A. Olschowska and D. Livnat: J. Immun. 135. 755s (1985). Immunomodulant therapy in Alzheimer's disease 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 41 E. M. Smith and J. E. Blalock: Proc. nat1 Acad. , USA 78,7530 (1981). E. M. Smith, D. Harbour-McMenamin and J. E.

Presynaptic events: neurotransmitter system 51 Results of experiments on animal models had shown that increases in rat brain ACh could be induced by administration of Ch or of deanol (121). , in aging. An example of significant behavioral effects is the superior maze learning of old mice when supplemented with lecithin (l08). The possibility that supplements of lecithin during pregnancy might have adverse effects on offspring has recently received some attention (19). Pregnant rats were exposed to a 2 % or 5 % soy lecithin preparation or to a normal diet at three time periods: life long beginning at gestation; during the time preceding gestation only; and, following weaning.

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